Georgia Institute of Technology
University of Delaware
University of Kentucky
Last Reviewed: 10/04/2017
The Center for Pharmaceutical Development (CPD), provides a forum for academic and industrial scientists to develop novel approaches for the improvement of pharmaceutical API manufacturing, drug product formulation, and analytical methods.
The Center for Pharmaceutical Development (CPD), established in February 2010, provides a forum for academic and industrial scientists to develop novel approaches for the improvement of pharmaceutical API manufacturing, drug product formulation, and analytical methods. The distinctive strengths of each of the University partners will provide industrial participants with unique opportunities to advance topics pertaining to these three key areas. The CPD facilitates technologies including but not limited to the following: the creation of robust biological and chemical catalysts with better selectivity that will allow for more streamlined processes, the development of improved methods for stabilizing pharmaceuticals to protect the nation’s drug supply, and the design of new analytical techniques for the nondestructive, accurate, and rapid evaluation of pharmaceutical products.
Our mission is to create more selective and robust biological and chemical catalysts, to develop methods for stabilizing drugs and vaccines, and to design new techniques for nondestructive evaluations of pharmaceutical products.
Develop a better understanding of raw materials quality and its effect on product performance
Development of raw materials critical quality attribute variability database to improve manufacturability and enhance the prediction of dosage from performance and non-destructive prediction of the physical and chemical stability of dosage forms
Develop methods to ensure long-term stability of tablets, proteins and vaccines
Develop more selective and robust processes with less environmental footprint
We seek to enable novel routes to small-molecule targets through the finding of new and improving of existing biocatalysts and chemical catalysts. In addition, we seek to conceive new ways for the achievement of condensations in aqueous solutions and for the formation of the integration of reaction and product/(bio) catalyst separation, all with the goal of rapidly scaleable, robust, and thus economical processes.
Develop novel analytical approaches and testing protocols for the prediction of drug stability
New methods for accelerated and non-accelerated stability testing of pharmaceutical products will reduce the time required for stability testing, simplify the experimental designs of stability studies and enhance the shelf-life of pharmaceutical products through better understanding of chemical and physical degradation mechanisms and improved time resolution.
Patents & Publications
Amine Dehydrogenase: Sequences and Process
Highlights: Technology Transfer:
Amine dehydrogenase gene and/or protein sent to three companies
• “Development of a Novel Amine Dehydrogenase for Synthesis of Chiral Amines“, M.J. Abrahamson, E. Vazquez-Figueroa, N.B. Woodall, J.C. Moore, A.S. Bommarius, Angew. Chem. Intl. Ed. 2012, 51, 3969-3972
• “The Evolution of an Amine Dehydrogenase Biocatalyst for the Asymmetric Production of Chiral Amines“,M.J. Abrahamson, J.W. Wong, A.S. Bommarius, Advanced Synthesis & Catalysis 2013, 102, 377-386
• “Novel Protease Inhibitors via Computational Redesign of Subtilisin BPN′ Propeptide”, A.B. Daugherty, P. Muthu, S. Lutz, Biochemistry, 2012, 51 (41),8247-8255
• “Salt-Induced Aggregation of a Monoclonal Human Immunoglobulin G1”, J. Rubin, L. Linden, W.M. Coco, A.S. Bommarius, S .Behrens, Journal of Pharmaceutical Sciences, 2013, 102, 377-386
• “Molecular Dynamics Simulation of Amorphous Indomethacin–Poly(Vinylpyrrolidone) Glasses: Solubility and Hydrogen Bonding Interactions”, Tian-Xiang Xiang and Bradley Anderson, Journal of Pharmaceutical Sciences 2013, 102,876–891
University of Delaware
Admin Assist: Kristi Halberg firstname.lastname@example.org
Department of Chemical & Biomolecular Engineering, 223 Colburn Lab
Newark, Delaware, 19716