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Bioanalytic Metrology (CBM)

Indiana University

Purdue University

University of Notre Dame

Last Reviewed: 11/08/2019

The Center for Bioanalytic Metrology (CBM), a partnership between the University of Notre Dame, Indiana University, and Purdue University, advances U.S. competitiveness by working with industry to solve current, emerging, and industry-relevant challenges in measurement science and technology. The center has two over-arching objectives: (1) deliver best-in-class molecular measurement tools and expertise that enable the development of powerful new pre-competitive technologies and capabilities across the pharmaceutical, biotechnology, food/nutrition/agriculture, energy and analytical instrumentation sectors; and (2) serve as a proving ground for applications of new instrumentation to cutting-edge chemical and biochemical problems.

Center Mission and Rationale

Measurement science, and associated instrumentation, is a key contributor to the U.S. economy, enabling advances in everything from drug discovery to materials manufacturing. By bringing together companies in these high-technology sectors with major analytical instrument makers, the CBM bridges the gap between the initial demonstration of new ideas—the traditional province of academia—and the delivery of practical pre-competitive technologies. Just as important, the CBM provides U.S. industry with compelling opportunities to invigorate human resources through access to a diversity of center-trained students and opportunities for continuing education of existing staff.

Research program

Bioanalytics

The CBM provides its members with research solutions in a variety of areas, including:

  • Ultrahigh sensitivity assays for trace-level biomarkers and impurities;
  • Discrimination between large biomolecules and their multi-molecule complexes;
  • Reduced volume/materials analysis and experimentation at high throughput and productivity;
  • Analysis of rare/extremely dilute cells/molecules/exosomes, etc.;
  • Massively parallel approaches to chemical cytometry, genetic profiling, and panel screening;
  • Online and near-line in situ measurements;
  • Point-of-use analysis, companion diagnostics, and inexpensive testing in the field;
  • Artificial intelligence-driven instrumentation, feedback optimization, and "driverless" instruments; and
  • Enhanced imaging of cells, organisms, and chemical processes.

Locations

University of Notre Dame

105 McCourtney Hall

Notre Dame, Indiana, 46556

United States

Indiana University

Department of Chemistry

Bloomington, Indiana, 47405

United States

Purdue University

Department of Chemistry

West Lafayette, Indiana, 47907

United States